Mixtures of hyaluronic acid (HA) and liposomes are efficient drug delivery systems for applications in otology and ophthalmology, yet little is known about their microstructure. In this study, we used SANS to demonstrate that liposomes keep their integrity in a matrix of HA chains, whether they are anionic, cationic, or decorated by poly(ethylene glycol) chains, and whether they contain or not a corticoid. We also demonstrate that their aggregation state is driven by how their surface interacts with the HA chains.
Publication: Hybrid systems combining liposomes and entangled hyaluronic acid chains: influence of liposome surface and drug encapsulation on the microstructure, C. Jaudoin et al., J. Colloid. Int. Science 628 (2022). https://doi.org/10.1016/j.jcis.2022.07.146