An enzyme in action seen by high-resolution quasielastic neutron scattering

Here we report on a recent study of Phosphoglycerate Kinase with high-resolution quasielastic neutron scattering (QENS) in which the data analysis with a “minimalistic” multi-scale model for protein dynamics in space and time shows directly that the transformation of adenosine diphosphate (ADP) into adenosine triphosphate (ATP), and thus the production of energy carriers within the living cell, is enabled by inter-domain motions of this enzyme.

Publication: Signature of functional enzyme dynamics in quasielastic neutron scattering spectra: The case of phosphoglycerate kinase, A. Hassani et al., J. Chem. Phys. 159 (2023).